Abevmy - 400mg/4ml


Description


Abevmy 400mg which contains the active ingredients Bevacizumab a humanized monoclonal antibody in which they are proteins and joins to other unique protein in body.
Abevmy 400mg has effect will interfere with growth of tumors by blocking the blood vessels growth providing the nutrients and oxygen to the tumor.
Abevmy 400mg mainly recommended for advanced cancer in large bowel i.e. colon or rectum, non-small cell lung cancer and advanced kidney cancer.
Abevmy 400mg is administrated under supervision monitoring by doctor.


Prescribed For


Abevmy 400mg injection is an antineoplastic drug which is indicated for the treatment, prevention, control and recovering from following diseases:
• Metastatic colorectal cancer (mCRC)
• Non – squamous non-small cell lung cancer (NSCLC)
• Glioblastoma
• Metastatic renal cell carcinoma (mRCC)
• Persistent, recurrent or metastatic carcinoma of the cervix
• Platinum – Resistant Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer








Dosage & Administration


Metastatic colorectal cancer (mCRC):
Abevmy 400mg recommended dose, given as an IV infusion, is as follows: First-line Treatment: 5 mg/kg of body weight once every 2 weeks or 7.5 mg/kg of body weight given once every 3 weeks.
10 mg/kg of body weight for every 2 weeks or 15 mg/kg of body weight for once every 3 weeks for Second-line Treatment.
Abevmy treatment recommended to be continued until progression of the underlying disease.
Non – squamous non-small cell lung cancer (NSCLC):
Abevmy prescribed dose is 10 mg/kg of body weight administer for once every 2 weeks or 15 mg/kg of body weight once every 3 weeks administer IV infusion.
Abevmy treatment recommended to be continued until progression of the underlying disease.
Glioblastoma:
Abevmy recommended dose is 10 mg/kg of body weight given once every 2 weeks or 15 mg/kg of body weight given once every 3 weeks administer an IV infusion.
Kidney cancer:
Abevmy dose is 10 mg/kg of body weight for once every 2 weeks administer intravenous infusion.
Persistent, recurrent or metastatic carcinoma of the cervix:Abevmy in combination with paclitaxel and cisplatin or paclitaxel and topotecan: 15 mg/kg IV every 3 weeks
Platinum – Resistant Recurrent Epithelial Ovarian, Fallopian Tube Or Primary Peritoneal Cancer: Abevmy in combination with topotecan dose is 15 mg/kg of body weight for once every 3 weeks administer IV infusion.
Administration :
Abevmy administrated as an intravenous infusion
1st infusion: over 90minutes
Subsequent infusion: If first infusion tolerated administer over 60 minutes and If second infusion over 60minutes is tolerated then administer subsequent infusion over 30minutes.

Pharmacology


Abevmy 100mgis a type of class of anti-angiogenesis drugs and monoclonal antibody.
Mechanism of Abevmy 400mg by inhibiting the process of angiogenesis by aiming and preventing human vascular endothelial growth factor (VEGF).
Vascular endothelial growth factor (VEGF) is a small protein released by cells that have specific effects on the behavior of cells (cytokine) that will binds with its receptors in the cell leads to formation or angiogenesis of new blood vessel.
Distribution: volume of distribution 2.9 (22%)
Elimination: adults 20days (11 to 50 days),
Pediatric patient median 11.8 days for age 1 to 21 yrs.
Intravitreal: 5 to 10 days

Precautions


• Inform the doctor or pharmacist about allergic condition against Abevmy 400mg if you had, fluorouracil (Adrucil, 5-FU), any another regimen, or any of the compound in Bevacizumab tablets.
• Previously you have been taking or ever had DPD (dihydropyridine dehydrogenase) deficiency of enzyme. Inform the doctor about this then your doctor may preferably inform you avoid taking Abevmy 400mg.
• Consult with the doctor that you have or have ever had renal, hepatic, or cardiac problem
• Inform the doctor that are you pregnant or plan to become pregnant. Do not planto have children while on treatment with Abevmy 400mg. You should use an essential method of conceiving to prevent pregnancy in yourself or your partner during your treatment with Abevmy 100mgthe drug will harm the fetus.
• while on treatment with Abevmy 400mg not recommended for breast feeding

Drug Interaction


When Abevmy 400mg injection used in combination of interferon alfa, Carboplatin or paclitaxel will reduce paclitaxel exposure after 4 cycles of treatment.
Patients receiving paclitaxel and Carboplatin alone will have increased paclitaxel exposure at day 63.

Pregnancy


Category D: while administrating Abevmy 400mg in pregnant women, positive evidence on fetal risk depends on human studies but potential benefits by using the drug may have common risk against fetus.

Lactation


Abevmy 400mg is excreted into breast milk taking account on this, discussion should do on whether to discontinue the breast feeding or the drug. The drug is unsafe While using during breast feeding to their infants.

Overdosage


If overdose suspected, headache is occurred and seek to medical department or poison control helpline.

Storage


Abevmy 100mg is stored under 2-80C.
Keep the drug in the original carton for protect from light until time to use.
Do not shake the vial or freeze it.



Missed dose


If single doses missed by patients then administer the dose as soon you remember, if it is near to next dose then skip the missed dose and follow the regular schedule. Avoid taking extra dose at a time.


Missed dose


As If cannot follow regular dose schedule,then keep an alarm to remind your dose schedule. Please consult the doctor for any dose schedule changes or new schedule for equally missed dose.


Contraindication


Hypersensitivity to the active substance of Abevmy 400mg or to any of the excipients.


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