AFATINIB 40MG


Description


Xovoltib 40mg belongs to the class of medications called protein kinase inhibitors. Xovoltib 40mg is a targeted therapy drug used to treat non-small cell lung cancer (NSCLC). It may also be used to treat other cancers as part of clinical trial. Xovoltib 40mg is a prescription drugs which is used under the supervision of medical practioners.


Indication


Xovoltib 40mg is used for the first-line therapy of patients with metastatic non-small cell lung cancer(NSCLC) whose cancer have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) changes mutations as detected by an FDA-approved test.


Dosage and administration


For adult the dose for metastatic non-small cell lung cancer is the usual dose is 40mg taken once per day. For child dosage ages of 0-17 years is not been studied in children. The drug should not be used age under 18 years of age For renal impairment: usual dose is 30mg taken once per day Take Xovoltib on an empty stomach. Consume the drug 1 hour before or 2 hours after a meal Avoid cutting or crushing the tablet







Mechanism Of Action


Xovoltib 40mg stops the activating sites called tyrosine kinases of various proteins within the cell. These proteins are most likely to develop cancer growth when the tumor includes the EGFR gene mutation. By stopping these targets, it will target the cancer will shrink.

Precaution


If patients have some serious condition then avoid the drug because the conditions will worse, the conditions like :
Embryo-fetal toxicity: Xovoltib 40mg will cause harm to the foetus when administrated to pregnant women
Keratitis: if patients confirm with suspected keratitis or ulcerative keratitis then stop or discontinue the drug
Hepatic toxicity
Interstitial lung disease (ILD)
Bullous and exfoliative skin disorders
diarrhae.

Drug Interaction


While concomitant use with P-gpinhibitors (cyclosporine A, ketoconazole verapamil) with Xovoltib 40mg will increase exposure to Afatinib
While co administration with P-gpinducers (carbamazepine, phenytoin, phenobarbital) with Xovoltib 40mg will decrease exposure to Afatinib

Side Effects


• Loss of appetite
• Nausea
• Vomiting
• Diarrhoea
• Mouth sores
• Acne
• Itchiness
• Rash
• Dry skin
• Nail infection
Serious side effects :
• Breathing trouble
• Cough and fever
• Yellowing the skins
• Brown coloured urine
• Bleeding or bruising
• Weakness
• Blurred vision
• Fast heartbeat.

Pregnancy


When the drug Xovoltib 40mg is administrated to a pregnant woman will harm the foetus. Pregnancy should avoid while on treatment with Xovoltib 40mg

Storage


Xovoltib 40mg Store at 250C
Keep Xovoltib 40mg away from children.



Lactation


Xovoltib 40mg Excretion into human milk is unknown or will have adverse reaction in a child who is breastfed.
Therefore, decision should take whether to stop breastfeeding or discontinuation of medicine.


Missed dose


If patient fail to take the dose of Xovoltib 40mg, must consult with medical oncologist and follow the suggestions Do not self-medicate. The missed dose must be skipped and follow the regular dosing schedule Do not double the dose


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