Bortenat 2mg belongs to class of anti-cancer medicine, which is in the form of lyophilized powder A first beneficial proteasome inhibitor is known as Bortenat 2mg; proteasome is a cellular structure which breaks the proteins

Dosage & Administration

Bortenat (lyophilized powder form) is reconstituted by using 0.9% sodium chloride (NS) Bortenat should be reconstituted in 3.5ml NS The route of administration is IV bolus Intrathecal not use for administration

Key points

Partially, 72 hours should be passing between following doses of Bortenat 2mg

Important points

Bortenat should be used alone or combination with dexamethasone Three week course is considered as therapy cycle A minimum 72 hours should slip away between constant doses of Bortenat


Mechanism of action :
Pharmacological category: anti-neoplastic agent or proteasome inhibitor Bortenat 2mg is a type of chymotrypsin like activity unpredictable inhibitor of the 26S proteasome in human cells. The 26S proteasome is a big protein multiplex which degraded the accompany proteins The functioning site of proteasome has Chymotrypsin like Trypsin like Postglutamyl peptide hydrolysis activity The 26S proteasome enzyme recede assorted proteins which demanding to tumor cells survival like cyclins, tumor suppressors, BCL-2 & cyclin dependent kinase inhibitors Prevention of these degenerations, sensitizes cells to apoptosis and cell arrest

Mantle cell lymphoma

The Bortenat recommended dose for untreated mantle cell lymphoma is; 1.3mg/m2 of Bortenat administered as IV bolus given as two times weekly by combining with rituximab, cyclophospahmide, doxorubicin and tablet prednisolone for two weeks (day I, IV, VIII & XI) followed rest period of 10 days (day II through 21). In Relapse stage: The usual dose of Bortenat is 1.3mg/m2 administered as IV bolus or subcutaneous two times for two weeks (day I, IV, VIII & XI) followed by 10 day rest period (day II through 21) The treatment continued for above 8 cycles may be taken for once weekly for 4 weeks (day 1, 8, 15 & 22), followed by 13 day rest (days 23 through 35)

Multiple myeloma

In the therapy of previously untreated multiple myeloma: 1.3mg/m2 of dose should be administered as 3 to 5 seconds through IV bolus or subcutaneous by combining with tablet melphalan and prednisolone for nine 6 weeks therapy cycles Cycles 1 over 4, Bortenat is taken for two times weekly, (day 1, 4, 8, 11, 22, 25, 29 and 32) Cycles 5 over 9, Bortenat is taken once a week (day 1, 8, 22, and 29)

In Relapse stage

The usual dose of Bortenat is 1.3mg/m2 should be administered through IV bolus or subcutaneous as two times for two weeks (day1, 4, 8, and 11) followed by a ten day rest course (day 12 through 21) Treatment schedule increased above 8 cycles may be taken once weekly for 4 weeks (day 1, 8, 15, and 22), followed by 13 day rest (day 23 over 35)

Drug Interaction

Strong CYP3A4 inhibitors: there is a chance of getting Bortenat 2mg toxicity; so to reduce the dose of Bortenat 2mg while concomitant with CYP3A4 inhibitors Strong CYP3A4 inducers: decrease the exposure of Bortenat 2mg Avoid concomitant with st. Johns wort to decrease the exposure of Bortenat 2mg No clinical effect on Bortenat 2mg exposure while concomitant with melphalan-prednisone or dexamethasone alone

Side effects

Most common side effects occurred after administration of Bortenat includes: Black tarry stools, Bleeding gums, Blood in urine, Blurred vision, Body aches, Burning, crawling, itching, numbness, prickling, Chest pain .
Cough producing mucus, dizziness, faintness, nerve pain, painful urination, pale skin, runny nose, sore throat, stuffy nose, swollen glands, sunken eyes, ulcer, dry mouth, ear congestion, loss of voice
Less common side effects:
irregular breathing , Swelling of peripheral organs ,Dilated veins, discomfort, increased sensitivity of pain & touch, , heart beats, , thickening of bronchial secretions loss of appetite, Muscle cramps Belching, bone pain, difficulty with moving & bowel movements, cold and shivering, , loss of taste, , muscle pain, stomach discomfort. Vomiting, loss of weight

Precaution & Warning

While taking Bortenat 2mg some adverse effects occurs care should be taken in the conditions like Bortenat 2mg leads to peripheral neuropathy like burning sensation, hyperesthesia, hypoesthesia, paresthesia, neuropathic pain Manage postural Hypotension by altering the antihypertensive agents, hydration, and administration of mineralocorticoids or sympathomimetics Cardiac toxicity Pulmonary toxicity like Acute Respiratory Distress Syndrome, pneumonitis, interstitial pneumonia, lung infiltration Posterior reversible encephalopathy syndrome-stop the Bortenat 2mg therapy Gastrointestinal toxicity-fluid or electrolyte replacements have to take Thrombocytopenia and neutropenia Tumor lysis syndrome Hepatic toxicity Embryo fetal toxicity

Pregnancy and lactation

Bortenat 2mg is not recommended in pregnancy condition, it causes harm to fetus Breast feeding is not recommended


Bortenat 2mg vial should be stored at 20oC to 25oC (68oF to 77oF) excursion between 15oC to 30oC (59oF to 86oF) Keep away from light and heat

Missed dose

Bortenat 2mg is not a normal medicine used as anti-cancer drug; it is not to be self-medicated.Please consult with physician and do not missed the cycles for course of therapy

Missed dose

If patient fail to take the dose of Bortenat 2mg, must consult with medical oncologist and followed the dosing schedules. Do not self administered


Hypersensitivity reaction occurs in patients who are contraindicated to Bortenat 2mg, boron, boric acid or glycine Bortenat 2mg< is given through IV bolus or subcutaneous; whereas intrathecal administration is contraindicated to the patients who are receiving Bortenat 2mg

Connect With Us

Prescription Medication Policy

1., a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from
6. At, a Caregiver can order prescription medicines on your behalf.