Cabometyx 40mg is a prescription drug which is used under the supervision of doctors
Cabometyx 40mg belongs to targeted therapy drug used to cure medullary thyroid cancer and kidney cancer that has spread and It is label includes a black box warning of gastrointestinal perforations, fistulas, and haemorrhage.
Cabometyx 40mg is used for the treatment of
Metastatic medullary thyroid cancer
Advanced renal cell carcinoma (RCC) who have getting before anti-angiogenic therapy.
Do not prescribe substitution for Cabometyx tablets with Cabozantinib capsules.
The usual dose of Cabometyx is 60 mg.
Administration Cabometyx is without food.
Inform the patients not to eat for at least 2 hours before and 1 hour after taking cabometyx. Follow the treatment until patient no longer experiences clinical benefit or experiences unacceptable toxicity.
Swallow Cabometyx tablets whole. Do not crush Cabometyx tablets.
Cabozantinib is a group of targeted therapy drug known as tyrosine kinase inhibitor. It works by prohibiting the signals inner cancer cells which made them develop and divide. This may help to restrict or reduced the development of the cancer. It can also prevent new blood vessels growing in the cancer. Cancer cells necessary to make new blood vessels, so they can grow and spread.
• Peak plasma concentration is observed in 2-5 hours
• Human plasma protein bounding of Cabometyx is ≥ 99.7%
• Mostly metabolized by CYP3A4 and minorly by CYP2C9
• Eliminated mostly via feces 54 % and in urine 27% and half-life is 55 hours
Monitor the patients for symptoms of perforations and fistulas, contain abscess. stop Cabometyx 40mg in patients who experience a perforation or a fistula.
Do not administer Cabometyx 40mg to patients with a present history of haemorrhage or haemoptysis.
Discontinue the Cabometyx 40mg in patients who develop an acute myocardial infarction, cerebral infarction, or any other clinically significant arterial thromboembolic complication.
Discontinuethe Cabometyx 40mg for patient if have severe hypertension that cannot be controlled with anti-hypertensive therapy.
Inform pregnant women about potential risk to a foetus. Advise females of reproductive possible to use efficient contraception during treatment with Cabometyx 40mg and for 4 months after the last dose
While combination with strong CYP3A4 inhibitor will increase the single dose plasma Cabometyx 40mg exposure by 38%.
While combination with strong CYP3A4 inducers will decreased the single dose plasma Cabometyx 40mg exposure by 77%
Concomitant use with MRP2 inhibitors may increase the exposure to Cabometyx 40mg
Based on studies of animal and mechanism of action, Cabometyx 40mg will cause fetal harm when given to pregnant women.
Advice the female not to become pregnant while on treatment with Cabometyx 20mg.
• GI perforations and fistulas
• Thrombotic events
• Hypertension and hypertensive crisis
• Palmar-plantar erythrodysesthesia
• Reversible posterior leukoencephalopathy syndrome.
If the patient vomits after taking a dose of Cabometyx 40mg or missed to take a dose, then should not to take an extra dose, but to take the next dose at the regular time, skip the missed dose. Do not take the missed dose within 12 hours of next dose.
During treatment with Cabometyx 40mg, advise the women not to breastfed to infants
Store the drug at 200C to 250C
Keep away from the children resistances
Cabometyx 40mg is contraindicated patients having hypersensitivity reaction to the active substance or its excipients.
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