Cizumab - 100mg



Description


Cizumab which contains the active ingredients Bevacizumab an humanized monoclonal antibody in which they are proteins and joins to other unique protein in body. Cizumab has effect will interfere with growth of tumors by blocking the blood vessels growth providing the nutrients and oxygen to the tumor. Cizumab mainly recommended for advanced cancer in large bowel i.e. colon or rectum, non small cell lung cancer and advanced kidney cancer. Cizumab is administrated under supervision monitoring by doctor.


Prescribed For


Cizumab injection is an antineoplastic drug which is indicated for the treatment, prevention, control and recovering from following diseases:
• Metastatic colorectal cancer (mCRC)
• Non – squamous non small cell lung cancer (NSCLC)
• Giloblastoma
• Metastatic renal cell carcinoma (mRCC)
• Persistent,recurrent or metastatic carcinoma of the cervix
• Platinum – Resisitant Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer


Administration of Cizumab


Cizumab administrated as an intravenous infusion 1st infusion: over 90minutes Subsequent infusion: If first infusion tolerated administer over 60 minutes and If second infusion over 60minutes is tolerated then administer subsequent infusion over 30minutes.




Dosage & Administration


Metastatic colorectal cancer (mCRC) :
Cizumab recommended dose, given as an IV infusion, is as follows: First-line Treatment: 5 mg/kg of body weight once every 2 weeks or 7.5 mg/kg of body weight given once every 3 weeks. Second-line Treatment: 10 mg/kg of body weight for every 2 weeks or 15 mg/kg of body weight for once every 3 weeks. Cizumab treatment recommended to be continued until progression of the underlying disease.
Non – squamous non small cell lung cancer (NSCLC):
Cizumab prescribed dose is 10 mg/kg of body weight administer for once every 2 weeks or 15 mg/kg of body weight once every 3 weeks administer IV infusion. Cizumab treatment recommended to be continued until progression of the underlying disease.
Giloblastoma:
Cizumab recommended dose is 10 mg/kg of body weight given once every 2 weeks or 15 mg/kg of body weight given once every 3 weeks administer an IV infusion.
Kidney cancer:
Cizumab dose is 10 mg/kg of body weight for once every 2 weeks administer intervenous infusion.
Cizumab dose is 10 mg/kg of body weight for once every 2 weeks administer intervenous infusion.
Cizumab in combination with paclitaxel and cisplatin or paclitaxel and topotecan: 15 mg/kg IV every 3 weeks
Platinum – Resisitant Recurrent Epithelial Ovarian, Fallopian Tube Or Primary Peritoneal Cancer:
Platinum – Resisitant Recurrent Epithelial Ovarian, Fallopian Tube Or Primary Peritoneal Cancer:

Mechanism Of Action


Cizumab is a type of class of anti angiogensis drugs and monoclonal antibody. Mechanism of Cizumab by inhibiting the process of angiogenesis by aiming and preventing human vascular endothelial growth factor (VEGF). Vascular endothelial growth factor (VEGF) is a small protein released by cells that have specific effects on the behavior of cells ( cytokine) that will binds with its receptors in the cell cause to new blood vessel formation or angiogenesis. Distribution: volume of distribution 2.9 (22%) Elimination: adults 20days (11 to 50 days), Pediatric patient (age 1 to 21 yrs); median 11.8 days Intravitreal : 5 to 10 days

Drug Interaction


When Cizumab injection used in combination of interferon alfa, Carboplatin or paclitaxel will reduce paclitaxel exposure after 4 cycles of treatment. Patients receiving paclitaxel and Carboplatin alone will have increased paclitaxel exposure at day 63.

Precautions


• Inform the doctor or pharmacist about allergic condition against Cizumab if you had, fluorouracil (Adrucil, 5-FU), any another regimens, or any of the compound in Bevacizumab tablets.
• You have been previously taking or ever had DPD (dihydropyrimidine dehydrogenase) deficiency of enzyme . Inform the doctor about this then your doctor may preferably inform you avoid taking Cizumab.
• Inform the doctor that you have or have ever had renal, hepatic, or cardiac problem
• Inform the doctor that are you pregnant or plan to become pregnant. Avoid planning to have children while on treatment with Cizumab. You should use a essential method of conceiving to prevent pregnancy in yourself or your partner during your treatment with Cizumab The drug will harm the fetus.
• Avoid breast feeding while on treatment with Cizumab

Pregnancy


Category D: while administrating Cizumab in pregnant women, positive evidence on fetal risk depends on human studies but potential benefits by using the drug may have common risk against fetus.

Lactation


Cizumab is excreted into breast milk taking account on this, discussion should done on whether to discontinue the breast feeding or the drug. While using the drug is unsafe during breast feeding to their infants.

Overdosage


If overdose suspected, headache is occurred and seek to medical department or poison control helpline.

Storage


Cizumab is stored under 2-80C Keep the drug in the original carton for protect from light until time to use. Do not shake the vial or freeze it.



Missed dose


If single doses missed by patients then administer the dose as soon you remember, If it is near to next dose then skip the missed dose and follow the regular schedule. Avoid taking extra dose at a time.


Missed dose


As If cannot follow regular dose schedule,then keep an alarm to remind your dose schedule. Please consult the doctor for any dose schedule changes or new schedule for equally missed dose


Contraindication


Hypersensitivity to the active substance of Cizumab or to any of the excipients.


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