Cyramza 100mg


Description


Cyramza 100mg belongs to Intravenous human monoclonal antibody which prohibits VEGFR2and it is used for advanced gastric or gastro-oesophageal junction adenocarcinoma, as a single agent or in combination with paclitaxel used for metastatic non-small cell lung cancer in combination with docetaxel used for metastatic colorectal cancer in combination with FOLFIRI Cyramza 100mg Increased risk of haemorrhage that may be severe and sometimes fatal. Discontinue if severe bleeding occurs.
Cyramza 100mg is a prescription drugs which is used under supervision of doctor.


Indication


Cyramza 100mg injection indicated for :
As a single agent, or in combination with paclitaxel for the treatment of advanced or metastatic gastric or gastroesophageal junction adenocarcinoma with disease progression on or after prior fluoropyrimidine or platinum containing chemotherapy.
In combination with docetaxel for the treatment for metastatic non-small cell lung cancer with disease progression on or after platinum-based chemotherapy.
In combination with FOLFIRI for the treatment of patients with metastatic colorectal cancer with disease progression on or after prior therapy with bevacizumab, oxaliplatin and a fluoropyrimidine








Dosage & Administration


Non-Small Cell Lung Cancer :
The recommended dose is 10 mg/kg IV infused over ~1 hr prior to docetaxel (75 mg/m²) IV infusion on Day 1 of a 21-day cycle
Continue until disease progression or unacceptable toxicity
Gastric Cancer :
As a monotherapy agent or in co administration with paclitaxel is used.
Recommended dose for Single agent or in combination with paclitaxel is 8 mg/kg IV q2wk; infuse over 1 hr
Recommended dose for Paclitaxel (if given in combination) is 80 mg/m² once weekly for 3 weeks of every 28-day cycle.
When given in concomitant, administer ramucirumab prior to administration of paclitaxel
Follow until disease progression or unacceptable toxicity
Colorectal Cancer:
In combination with FOLFIRI for the treatment
Recommended dose is 8 mg/kg IV q2wk; administer by IV infusion over 60 minutes prior to FOLFIRI administration
Follow until disease progression or unacceptable toxicity

Mechanism Of Action


Ramucirumab belongs to human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), which is a type II trans-membrane tyrosine kinase receptor show on endothelial cells. By binding to VEGFR2, ramucirumab inhibits binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), hence prohibiting VEGF-stimulated receptor phosphorylation and downstream ligand-induced multiplication, permeability, and migration of human endothelial cells.
Half-life of ramucirumab 14 days

Precautions


Raised the risk of haemorrhage and gastrointestinal haemorrhage, containingserious and sometimes fatal haemorrhagic events enduringly discontinue patients who experience severe bleeding
Can have high the risk of gastrointestinal perforation, a probably fatal event
Completely discontinue in patients who experience a gastrointestinal perforation
Impaired wound healing can appear with antibodies prohibiting the VEGF pathway
Stop in patients with impaired wound healing
Hold up drug prior to surgery and discontinue if a patient occurs wound healing complications

Drug Interaction


Cyramza 100mg has No clinically meaningful difference in the exposure of either ramucirumab or its combination drugs in the approved combinations, contains paclitaxel, docetaxel, and irinotecan were observed in patients with solid tumor.

Pregnancy


Cyramza 100mg has no available data while use in pregnant women to inform any drug–associated risks. Based on mechanism ramucirumab will cause fetal harm.

Side Effects


Cyramza 100mg have side effects for gastric cancer with combination of paclitaxel :
Fatigue/asthenia , Neutropenia , Diarrhea , Epistaxis , Peripheral edema, Stomatitis , Proteinuria , Hypertension, Infusion-related reactions, Hypertension grade 3-4, Thrombocytopenia , Hypoalbuminemia .
Cyramza 100mg have side effects for non-small cell lung cancer :
Neutropenia , Fatigue/asthenia , Stomatitis/mucosal inflammation , Epistaxis , Febrile neutropenia , Peripheral edema, Thrombocytopenia , Lacrimation increased , Hypertension .

Missed Dose


Take the dose immediately before next dose duration Next dose time reaches then left off the missed dose and continue regular schedule. Avoid taking double dose at same time. Please consult the doctor for further information.



Lactation


Excretion into human milk is unknown. Avoid the Cyramza 100mg during treatment.


Storage


Discard product if it contains particulate matter, is cloudy, or discoloured Dispose unused portion. Do not store for later use. Avoid freeze. Protect from light.


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