Herduo 250mg


Herduo belongs to class of anti-neoplastic drugs which prevents the development and spreading of cancer cells all over the body. Herduo is indicated for metastatic breast cancer and spreading after using of other chemotherapy drugs


Herduo is used with combination of capecitabine for the treatment of advanced breast cancer after the failure of other cancer medicine. Herduo is also used with letrozole combination to treat postmenopausal women with hormone receptor positive metastatic breast cancer.


Herduo dosing for HER2 positive metastatic breast cancer (with Xeloda) is 1250mg once daily for 1-21days continuously repeating.
Combination with femora is 1500mg orally once a day continuously once daily every day.
Administrate Herduo on an empty stomach (1hr before or 1hr after).
If overdose occurs, seek to emergency department or call poison control helpline.

Mechanism Of Action

Herduo is a type of classification called kinase inhibitor and act by intracellular tyrosine kinase.
Herduo prohibits ErbB-forced tumor cell growth in vitro and in various animal models. When combination 5-fluracil with Herduo created an additive effect in the 4 tumor cell lines tested. Development inhibits the Herduo tablet effect were examined in trastuzumab-conditioned cell lines.
Herduo provide selective action against breast cancer cell lines selected for long-term growth in trastuzumab-containing intracellularly. Hormone receptor-positive breast cancer cells (with ER [Estrogen Receptor] and/or PgR [Progesterone Receptor]) that co express the HER2 bear to be protection against established endocrine therapies. Simultaneously hormone receptor-positive breast cancer cells that initially lack EGFR or HER2 unrecalled these receptor proteins as the tumor becomes resistant to endocrine therapy.


Poor absorbs from the GI tract. peak plasma concentration is approx. 4hrs ; bioavailability is 95%. Herduo with food will increase the systemic exposure.
Plasma protein binding is 99%
Herduo Metabolized mainly by CYP3A4 and CYP3A5.
Excreted dose through feces more than 14% and <2% urine. Eliminated half-life is 24hrs.


Herduo should avoided If you are allergic to lapatinib.
If you had hepatic problem, cardio disease, an electrolytic imbalance then discusses with doctor whether it’s safe to use or not prior to Herduo treatment.
Herduo should not prefer during pregnancy because it harm the unborn baby or cause birth defects.
Avoid breast feeding during Herduo treatment, it is not known whether Lapatinib passes into breast milk.

Drug interaction

Herduo regimen interact with Artemether, Etravirine,Pazopanib, Tacrolimus,Telithromycin,Topotecan,Tramadol,Tretinoin, Voriconazole, Ziprasidone. May increase risk of side effects and will not work properly and effect of Herduo may changes.


Herduo 250mg tablet has no adequate and well tolerated details about the drug.Herduo 250mg in pregnant women. Excretion into human milk is unknown. Avoid not become pregnant while receiving Herduo treatment.

Side Effects

Herduo will cause mild to moderate side effects in patients. If symptoms cause serious the inform the doctor as soon as possible.
Common side effect of Herduo 250mg tablets :
Lumbar pain; diarrhae; dry skin; nail of finger toe changes; headache; in digestion problem ; decreased appetite; mild hair loss or thinning; mouth ulcers; nausea; nosebleed; redness and tingling of the hands and feet; tiredness; difficult in sleeping; vomiting.
Serious side effect of Herduo 250mg tablets:
Severe tightness; difficulty in breathing; unusual bruising or bleeding; unusual itching; yellowing of the eyes or skin; pain in chest; dark urine; dizziness or light-headedness; fast or irregular heartbeat; pale stools; persistent loss of appetite; severe or persistent cough; severe or persistent diarrhea, nausea, vomiting and skin allergy like itching, rashes, blisters in mouth, face, lip or tongue.

Missed Dose

Take the missed dose as you remember soon before the next dose time. If time to next dose then skip the missed dose and go for daily schedule, don’t make up with extra dose. Please consult the doctor for further details.


Do not use the drug after the medication has expired. Keep away from the children. Dispose of medicine should consult with pharmacist for proper dispose of chemo drugs. Store at 25-300C.


Herduo is contraindicated to hypersensitivity condition. Tablet should avoid during condition of allergic reaction, breastfeeding,pregnant.

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