Hermab - 440MG

Describes As

Hermab 440mg injection consist a targeted cancer drug known as Trastuzumab, which is Pharmacologically grouped as humanized monoclonal antibody produced by recombinant DNA technology.
Hermab 440mg helps to reduce the rate of reactivation & mortality.
One of the epidermal growth factor receptor is known as human epidermal growth factor receptor 2 (HER2) plays vital role in breast cancer. This factor is responsible for cell replication.
An FDA approved product Hermab 440mg which is involved in breast cancer treatment.
Hermab 440mg vial with 858mg of lyophilized powder containing 150mg of Trastuzumab .


The drug Hermab 440mg is indicated for the treatment of following conditions:
Supportive treatment for breast cancer
Advanced breast cancer
Advanced gastric cancer.

Dosage & Administration

Breast cancer Metastatic HER2-Overexpressing:
• Over a 90 minute, 4mg/kg alone or with combination of paclitaxel in initial dose.
• Over 30 minutes, 2mg /kg once in a week for maintenance dose.
• Duration of therapy for initial and maintenance dose until disease progression.
Adjuvant regimen for HER2 over expressing Breast cancer:
52 weeks of treatment total schedules as follows:
• Combination With paclitaxel or docetaxel, overa 90 minute, 4mg/kg IV then over 30 minutes, 2mg /kg for 12 weeks or combination with Carboplatin/ docetaxel for 18 weeks one week following the last weekly dose.
• Over 30 to 90 minutes, 6mg/kg IV for every 3 weeks.
Esophageal carcinoma or gastric cancer for adult dose:
• 8mg/kg IV over 90 minutes as initial dose
• 6mg/kg IV over 30 to 90 minutes for every 3 weeks as maintenance dose
• Duration of therapy for initial and maintenance dose until disease progression.
Hermab is administer into vein through IV infusion over 90 minutes
Do not administer IV push or bolus.
Duration of Hermab is administratedin once every week or every 3 weeks.
Before starting treatment, patients should undergo biopsy to check Hermab is the right regimen the infusion solution should be compatible to polyvinyl chloride or polyethylene bags.
After dilution, the infusion bag should be stored at 2oC to 8oC for not more than 24 hours before use.
Over dosage :
Maximum dose of Trastuzumab is more than 8mg/kg as a single dose. In case of over dosage condition, patient must be; Provide with supportive measures Monitor the signs & symptoms due to over dosage


Volume of distribution: 44 mL/kg as trastuzumab; 3.13 L as trastuzumab emtansine.
As trastuzumab emtansine: which Undergoes deconjugation and catabolism through proteolysis in cellular lysosomes.
Terminal Elimination half-life is 6 days (weekly dosing); 16 days (3 weekly regimen); approx 4 days as trastuzumab emtansine.
Elimination of drug includes clearance of IgG through the reticuloendothelial system.


Hermab 440mg is a type of monoclonal antibody which targeting the HER2, provoke a resistant mediate reaction which causes disguise and down regulation of HER2.
HER2 pathway is specific for cell proliferation, joining of Transtuzumab to the site of HER2 causes prevention of this activity.
This joining leads to antibody mediated and leads to HER2 positive cells break down.
Hermab 440mg is a intermediary of anti-body dependent cellular cytotoxicity.

Drug Interaction

Hermab 440mg interaction with anthracycline after ending of Hermab 440mg treatment may have a chance of getting cardiac problem. This side effects occur because of Transtuzumab great disaster period is depends on population PK analysis.
Do not take anthracycline treatment for 7 months after stopping the Hermab 440mg treatment.
In some phenomenal condition, patient should get anthracycline, in that situation patient’s cardiac function should be checked carefully with regular intervals.

Safety Precautions

Hermab 440mg receiving patients have increased risk of exposing to cardiac disorders.
To overcome the problem by;
Monitoring cardiac functions regularly
Avoid using anthracycline drug after Hermab 440mg treatment
Provide alternative therapy management
In serious condition, treatment should be discontinuing.
Infusion reactions;
During Hermab 440mg treatment some life-threatening infusion reactions are produced.
The manifestation due to infusion reactions should be monitored frequently
Delay the infusion of Hermab 440mg treatment and Start the supportive measures by providing epinephrine, corticosteroids, diphenhydramine, bronchodilators, & oxygen.
In serious infusion reactions, Stop the Hermab 440mg treatment permanently.
Patient should be treated with premedication before starting the infusion to overcome the such problem, Embryo fetal damage;
Hermab 440mg is contraindicated to pregnancy period.
Avoid becoming pregnancy during this therapy.
Use efficient contraceptives during treatment Pulmonary toxicity;
Some serious fatal cases of pulmonary toxicity occur during Hermab 440mg treatment.
During Hermab 440mg treatment. Use with Caution. Therapy induced neutropenia;
Higher incidence of neutropenia occurs during Hermab 440mg treatment.

Missed dose

If missed cycles of Hermab 440mg treatment by one week or less, then the repeated maintenance dose (weekly schedule: 2mg/kg; 3 weekly schedules: 6mg/kg) administer as soon as probably.
Until the next planned cycle, the patient does not take interval.
Consecutive Hermab 440mg maintenance dose should be taken in 7 days or 21 days next confer to the weekly or 3 weekly schedules.
If patient missed to take Hermab 440mg dose by higher than one week, then resume with re-storing dose of Hermab 440mg such as weekly schedule is 4mg/kg; 3 weekly schedules is 8mg/kg should be administered over period of 90 minutes.

Side Effects

The most common adverse effects;
Cardiomyopathy, Infusion reactions, Embryo fetal toxicity, Pulmonary toxicity, Chemotherapy induced neutropenia. The most common side effects;
Hypertension, Influenza, Dyspnae, URI, Rhinitis, Pharyngolaryngeal pain, Sinusitis, Epitasis, Pulmonary hypertension, Dizziness, Decrease LVEF, Palpitations, Arrhythmia, Cardiac failure, Cough, Interstitial pneumonitis, Diarrhea/constipation, Nausea, vomiting, Dyspepsia, Autoimmune thyroiditis, Neutropenia, Hypokalemia, Anemia, Thrombocytopenia, Febrile neutropenia, Renal failure, Abdominal pain, Arthralgia, Back pain, Bone pain, Headache, Paresthesia, Rash,, Nail disorders, Pruritus, Pyrexia, Chills, Edema, Asthenia, Sudden death.

Pregnancy and lactation

Hermab 440mg pregnancy category is D
Hermab 440mg should not suggest during pregnancy condition.
Breast feeding should not be recommended.


Hermab 440mg vials should be stored at refrigerator temperature of 2oC to 8oC. Keep the vial away from heat & light. After reconstitution, vial should be stored at 2oC to 8oC for 28 days. Stored Hermab 440mg diluted bag at 2oC to 8oC for 24 hours


No possible contraindicated occurs.
Infusion reactions are produced.
The patients are contraindicated to the component present in the Hermab 440mg, Hence Hypersensitivity reactions are occurring.

Connect With Us

Prescription Medication Policy

1. Anti-Cancer-Drugs.com, a fully licensed and regulated pharmacy, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.
2. Anti-Cancer-Drugs.com will not dispense any prescription medication without a valid prescription from a licensed physician.
3. If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.
4. The drug information provided in the Anti-Cancer-Drugs.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.
5. Anti-Cancer-Drugs.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Anti-Cancer-Drugs.com
6. At Anti-Cancer-Drugs.com, a Caregiver can order prescription medicines on your behalf.