Lenalid - 25mg

Lenalid 25mg clinical uses


The primary uses of Lenalid 25mg capsules are;
Multiple myeloma
Lenalid 25mg is involved in the therapy of multiple myeloma by combining with dexamethasone.
Lenalid 25mg is shown as upkeep treatment in patients with MM following autologous hematopoietic immature microorganism transplantation (auto-HSCT).
Myelodysplastic syndromes
Mantle cell lymphoma: Lenalid 25mg is used for this condition in patients who are already receiving Bortezomib therapy priory.

How Lenalid 25mg works in a body


Lenalid 25mg involves in the inhibition of tumor necrosis factor alpha formation, which encourage the T-cells and causes diminishing serum levels of cytokines vascular endothelial growth factor & basic fibroblast growth factor. Lenalid 25mg is also involved in the prohibition of angiogenesis. Lenalidomide is also encouraged G1 cell cycle arrest & apoptosis of destructive cells.


Lenalid 25mg therapeutically classified as


Lenalid 25mg consisting Lenalidomide has various activities; 1. Immuno modulatory agent
2. Anti-angiogenesis agent
3. Anti-neoplastic agent




Describes as


The Lenalid 25mg capsules are containing an active substance known as Lenalidomide which is an analogue of thalidomide with potent anti-neoplastic activity.


Lenalid 25mg dosage


The usual dose of Lenalid 25mg in myelodysplastic syndromes is 25mg should be administered as once a day. For renal damaged patients; Patients with CrCl >60ml/min should not require dosage adjustment. Patients with CrCl 30 to 60ml/min, 25mg of Lenalid 25mg should be administered as once a day. Patient with CrCl <30ml/min, 2.25mg of Lenalid 25mg should be given orally as a once a day.
Dosage alteration:
Thrombocytopenia:
Drops to <50000/mcL, therapy should be postponed. Back to > or equal to 50000/mcL, continue the Lenalid 25mg with 25mg/day.
Neutropenia;
Drops to <500/mcL, therapy should be postponed. Back to > or equal to 500/mcL, treatment should be continue to 25mg/day.

How the body works for Lenalid 25mg


The absorption of Lenalidomide is occurs very quickly and reaches maximum plasma concentration with the range of 0.5 to 6 hours. The human plasma protein binding capacity of Lenalidomide is occurs by 30%. The metabolism of Lenalidomide is undergoes in limited events. In humans, the unchanged form of Lenalidomide is the most dominant circulating component. Two major metabolite of Lenalid 25mg; 5 hydroxy Lenalidomide N-acetyl Lenalidomide Nearly 90% & 4% of dose should be eliminated via urine & feces. This may occurs within 10 days. 82% of radioactive dose of Lenalidomide should be eliminated via urine within 24 hours. The mean half life period of Lenalid 25mg is 3 to 5 hours in multiple myeloma patients.

Multiple myeloma


In this condition, Lenalid 25mg is combined with dexamethasone. The prescribed dose of Lenalid 25mg is 225mg should be administered as once daily on day 1 to 21. The dose of dexamethasone; 40mg of dexamethasone should be followed on day 1 to 4, 9 to 12 & 17 to 20 of each 28 day cycles. Patient with >75 years, 20mg of dexamethasone should be recommended on day 1, 8, 15, & 22.

Mantle cell lymphoma


The advised dose of Lenalid 25mg for this condition is 225mg should be administered orally as once daily. For renal damaged patients; CrCl 30 to 60ml/min, 25mg of Lenalid 25mg should be administered as once daily. CrCl <30ml/min, 125mg of Lenalid 25mg should be used for q48hr. Pediatrics; The potency & effectiveness of Lenalidomide has not been evaluated in pediatric patients with age of <18 years.

Lenalid 25mg interacts with


Lenalid 25mg with digoxin causes elevation of both Cmax & AUCinf of digoxin. Avoid this concomitant use. Patients should be monitored with digoxin plasma levels. Lenalid 25mg with Erythropoietic agents causes increased exposure of thrombosis. Patient should be counseled before starting the treatment about the risk benefit of these combinations. In multiple myeloma condition, Lenalid 25mg is combining with warfarin. In this condition both prothrombin time & INR value should be monitored periodically

storage


Lenalid 25mg capsules container should be stored at temperature of 20oC to 25oC. Keep the container away from heat, moisture, & light.

Avoid missed dose


In case of missed dose occurs, patient must be consult with medical oncologist and follow the regular schedule. The over dosage of Lenalid 25mg is treated by providing some general supportive measures. The manifestation due to over dosage of Lenalid 25mg should be monitored frequently The over dosage of Lenalid 25mg caused neutropenia & thrombocytopenia Monitor the blood counts periodically.

Lenalid 25mg undesirable effects


Adverse effects; Fetal toxicity, Hematological toxicity, Elevation of mortality rate, Second primary malignancies, Liver toxicity, Hypersensitivity reactions, Tumor lysis syndrome, Tumor flare reactions, Thyroid disorders.
Common side effects;
Fatigue, Asthenia, Pyrexia, Pain, Diarrhea, Dyspepsia, Bone pain, Neck pain, Muscle weakness, pain, Respiratory infections, UTI, Influenza, Sepsis, Headache, Anemia, Loss of appetite, Hypokalemia, Hyperglycemia, Hypocalcaemia, Dehydration, Gout, Diabetes mellitus, Rash, Insomnia, Depression, Deep vein thrombosis, Myocardial infraction, Renal failure, Squamous cell carcinoma, Basal cell carcinoma.

Warning should be given for patient taking Lenalid 25mg capsules


Lenalid 25mg do not take at pregnancy period, it causes fetal harm and leads to embryo fetal toxicity concludes as death. Use effective contraceptives during Lenalid 25mg therapy for avoiding become pregnant. Frequent blood cells count should be performed by undergoing CBCs. Blood clotting is the major risk factor occurs during the therapy of Lenalidomide. Clotting may occurs mostly in arms, legs & lungs, this may concludes as heart attack & sometimes stroke also occurs. The most dominant warning signs of Lenalidomide
Embryo fetal damage
Neutropenia
Thrombocytopenia
Venous & arterial thromboembolism



Pregnancy & lactation


Lenalid 25mg should not be used in pregnancy period Lenalid 25mg causes fetal damage and finally leads to death Breast feeding should not be suggested.


contraindicated to


Lenalid 25mg is contraindicated to pregnancy & lactating period. Anaphylactic reactions are produced because patients are contraindicated to the component of Lenalid 25mg .


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