Bendamustine is sold under brand name Leuben.
Leuben is type of cancer medicine which prevents the growth and spread of cancer cells in the body.
Leuben is a prescription drug which is used under the guidance of medical supervision
Leuben 100mg is indicated for the treatment of patients suffering with Chronic lymphocytic Leukaemia
Leuben 100mg is indicated for the treatment of patients suffering with Indolent B-cell non-Hodgkin’s lymphoma
Bendamustine belongs to group of chemotherapy drug Known as alkylating agent.
The mechanism of bendamustine by prevent the DNA in cancer cells. The cells can’t replicate into 2 new cells, so the cancer stops the grow
For chronic lymphocytic Leukaemia :
The prescribed dose is 100mg/m2 IV infusion on days 1 and 2 of 28-day cycle, repeated for up to 6 cycles
Non-Hodgkin Lymphoma :
The prescribed dose is 120mg/m2 IV infusion on days 1 and 2 of 21-day cycle repeated for up to 8 cycles
Time to peak plasma: At end of infusion
Protein bound: 94-96%
Volume of distribution: 25L
Metabolized by CYP1A2
Excretion: feces 90%; Urine 1-10%
Stop the treatment, if patients experience severe infusion reactions
When the treatment with Leuben will cause Mild-mod renal impairment, mild hepatic impairment
Probably of anaphylactic/infusion reactions: serious in rare cases
Myelosuppression may report; decrease dose; restart treatment based on ANC and platelet count recovery; difficult situation of myelosuppression may lead to death
Check further fever and other signs of infection and treat promptly
Leuben concomitant use with CYP1A2 inhibitors will have possible to increase plasma concentration of bendamustine and decrease plasma concentration of active metabolites.
Leuben concomitant with CYP1A2 inducers will have possible to decrease plasma concentration of bendamustine and increase plasma concentration of active metabolites.
Common side effects :
Decreased blood counts
Some rare side effects :
Pregnancy category is D
Based on adverse reaction, there is a positive symptom of human fetal risk
Do not use Leuben during pregnancy.
The drug excreted into human milk is unknown and effects in the new born baby are unknown
Hence use is contraindicated.
If dose is missed, then have immediately before the reaching of next dose time or swap the missed dose and continue regular schedule. Consult the doctors for more information
Store in refrigerator at 20 to 80C.
keep in original containers until time of use.
Known hypersensitivity to bendamustine and its metabolites
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