Pomalid - 4mg



Describe As


Pomalid 4 mg is therapeutically categorized as an anti-neoplastic agent, which is active in multiple myeloma condition. Pomalid 4 mg capsules are used by the patients who are having a prescription specify by practiced medical oncologist. Pomalid 4 mg capsules are indicated in the patients who are already receiving Lenalidomide & proteasome inhibitors. Pomalid 4 mg capsules are endorsed by FDA and which is applicable as orally bioavailable. Pomalid 4 mg contains Pomalidomidewhich is act as anti-cancer agent. Pomalidomideis a thalidomide analogue with efficient activities like; Anti-angiogenesis, Immuno modulatory & anti-neoplastic activity Pomalid 4 mg capsules are available in various strengths like 1mg, 2mg, and 4mg.


ADME Properties


Pomalid 4 mg peak plasma concentration time: 2 to 3 hours Pomalid 4 mg capsules should be administered with or without food. Apparent volume of distribution 62 & 138L Human plasma protein binding capacity is 12% & 44%. Metabolism initiated by CYP1A2 & CYP3A4. Clearance value 7 to 10L/hr Elimination occurs through feces & urine by 18% & 73%. The unchanged form of Pomalid 4 mg should be excreted via urine & feces by 2% & 8%. Half life period of Pomalid 4 mg is 9.5 hours.





Dosage & Administration


The most common indication of Pomalid is involved in the treatment of Multiple Myeloma condition. The usual advised dose of Pomalid is 4mg tablet should be administered orally as once a day for cycles of 1 to 21 days for ensuing 28 day cycles. During this treatment, Pomalid should be combinely used with low dose of dexamethasone. Dexamethasone should be administered on day 1, 8, 15 & 22 of every 28 days cycles. The recommended dose of dexamethasone; Pomalid treatment due to some hematological problems; In Neutropenia condition; ANC <500/mcL: The Pomalid treatment should be postponed and check the CBC weekly. ANC ≥ 500/mcL: The Pomalid therapy should be continued by 3mg/day For each successive drop <500/mcL: The Pomalid treatment should be postponed. ANC ≥ 500/mcL: Promote the Pomalid therapy with 1mg/day. Thrombocytopenia; Platelets count <25000/mcL: The Pomalid therapy should be postponed and check CBC Platelets count ≥50000/mcL: The Pomalid treatment should be taken daily as 3mg/day.

Concomitant use of CYP1A2 with Pomalid


In case of combination of Pomalid with CYP1A2 causes increasing the plasma concentration of Pomalidomide and leads to cause increased adverse effects. In this condition, reduce the dose of Pomalid

In hepatic damaged patients


Mild to moderate hepatic damage: The prescribed dose is 3mg of Pomalid should be taken. Severe liver damage: The prescribed dose is 2mg of Pomalid should be taken.

In renal damaged patients


In severe renal damage condition, the suggested dose is 3mg per day.

Safety Precautions


During Pomalid 4 mg treatment, patients should be very cautiously taking the doses. Two major life threatening conditions are occurred at the time of therapy; Venous & arterial thromboembolism Embryo fetal damage To avoid such conditions, patient should be taken some precautions like;

Embryo fetal toxicity


Pomalid 4 mg should not be used during pregnancy period. It comes under the category of X; may causes fetal toxic & leads to death. Use some special contraceptive techniques for preventing pregnant during the treatment. Pomalid 4 mg may causes Teratogenecity, organogenesis & this may concludes as fetal damage.

Venous & arterial thromboembolism


Deep vein thrombosis is the one of the major exposure occurs during the therapy of Pomalid 4 mg. To overcome the problem, thromboprophylaxis is initiated. In case of combination of pembrolizumab with thalidomide analogues & dexamethasone causes increasing rate of mortality. Especially in multiple myeloma adverse condition, this pembrolizumab with dexamethasone causes death rate in higher levels.

Hematological toxicity


The most common hematological disorders are neutropenia, & thrombocytopenia which may occurs during the treatment using with Pomalid 4 mg. Reduce this type of effect by undergoing CBC counts frequently and monitor the patients manifestation due to this adverse.

Hepatic toxicity


Hepatic associated adverse effects are mostly produced by elevation of hepatic enzymes levels. This may leads to severe hepatic failure. This condition may overcome by monitoring the patients hepatic function test regularly.

Neuropathy


Hepatic associated adverse effects are mostly produced by elevation of hepatic enzymes levels. This may leads to severe hepatic failure. This condition may overcome by monitoring the patients hepatic function test regularly.

Tumor lysis syndrome


During this adverse condition, Pomalid 4 mg therapy should be interrupt and follow the general supportive measures for the patients. Then the signs & symptoms occur due to this TLS should be monitored.

Therapeutic Indication


The therapeutic indication of Pomalid 4 mg is involved in condition like Multiple myeloma. In this condition, Pomalid 4 mg is utilized by consolidating with dexamethasone. Pomalid 4 mg cases are relevant in; Patients formerly regarded with two treatments, for example, proteasome inhibitor and Lenalidomide. Patients who are endured with illness movement condition Pomalid 4 mg treatment ought to be taken after inside 60 days in patients who are finished up the last treatment .

How Pomalid 4 mg Works


Pomalidomide has three noteworthy pharmacological exercises against tumor cells. Pomalidomide includes in impeding the malignancy duplication and creates the apoptosis of disease cells. Pomalidomide increase the T cell and natural killer cells interceding insusceptibility and forbid the development of professional provocative cytokines from monocytes. Pomalidomide obstructs the new cell development. The official of Pomalidomide to dynamic site of focused cell causes restriction of ubiquitin ligase activity.

Interacts With


The concomitant use of Pomalid 4 mg with CYP1A2 potent inhibitors like Fluoxamine which will lead to elevate the plasma concentration of Pomalidomideand increases the adverse effects related to the Pomalid 4 mgomide. Stop the condition by reducing the Pomalid 4 mg dosage.

Storage


Pomalid 4 mg capsules container should be keep in a temperature of 20oC to 25oC. Do not store the container in light Protect from moisture & heat

Lactation


Breast feeding should not be recommended.

Pediatric


The potency & effectiveness of Pomalid 4 mg should not be evaluated.



Pregnancy


Pregnancy category of Pomalid 4 mg is categorized as X X means causes fetal damage during the Pomalid 4 mg treatment. Pomalid 4 mg causes embryo fetal damage.


Geriatric


Dose change of Pomalid 4 mg ought not to be suggested. Geriatric patients with time of over 65 years ought to be knowledgeable about pneumonia.


Contraindication


Pomalid 4 mg is contraindicated to pregnant women. Some anaphylactic reactions are occurs because patients are contraindicated to the component in the Pomalid 4 mg capsules.


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