Sorafenat is sold under the trade name of sorafenib. Sorafenib is belongs to the group of tyrosine kinase inhibitor, or angiogenesis inhibitor. Sorafenat is a targeted treatment which is used only under the knowledge of medical oncologist. Sorafenat tablets may prohibits the cell growth. Sorafenat is a prescription drug.
Sorafenat is a chemotherapeutic drug used to treat hepatocellular carcinoma, renal cell carcinoma, differentiated thyroid cancer(liver,kidney,thyroid).
Sorafenat is a tablet form. Route of administration is through mouth
Duration : 2 times per a day without food
Recommended dose in adults: 400mg( 2 tablet of 200mg) BD
The time to peak plasma level is 3 hours. It administrated without food. bioavailability is 38-49%.
human serum protein binding is 99.5%
Sorafenat metabolized in liver by CYP3A4 and undergo oxidative metabolism and in glucuronidation by UGT1A9.
In oral administration the drug Excreted within 14 days of 96% dose and the drug eliminated via urine 19% as glucuronidated. and feces 77% .
Sorafenat inhibits the cell surface and intracellular kinase to reduces the growth of tumor cells. Sorafenat is a protein tyrosine kinase is a type of biological treatment. The kinase which work as chemical messenger and This enzyme enhances the cancer cells growth. It is also called as multi kinase inhibitor, since it stop most of the protein kinase. Action carried out by two way ,it will bind with the protein which normally help to grow tumor cells and other way it helps to block cancer cells forming from new blood vessels.
• Interaction of Sorafenat with carbamazepine + dexamethasone + Phenobarbital + phenytoin + rifamipicin leads to reduce in Sorafenib plasma concentration.
• Interaction of Sorafenat with with doxorubicin and irinotecan will cause plasma concentration increase.
If you have any allergies to medicines, you should inform your consultant before using Sorefenat and beware of prescription or over-the-counter medicinces you are currently taking must be informed to doctor.
If you have high blood pressure, bleeding problems, chest pain, heart problems, kidney problems ( not a kidney cancer), or liver disease. Sorafenib is not a suitable treatment. Check with your consultant if you have any of these disease.
Sorefenib can reduce fertility growth in pregnancy women, so consult your doctor if you are pregnant or planning to become pregnant, breast-feeding.
Pregnancy category: D Sorafenat is not used for pregnant women or women who become pregnant. Sorafenat causes Teratogenecity and fetal harm. During Lactation, avoid taking Sorafenat tablet. The drug is not recommended for breast feeding mother.
Erythema, Athralgia, Loss of weight,, Paresthesia, Dysesthesia, Weakness, Feeling tired, Diarrhea, Constipation.
Bleeding irregular, Black stools, Red blood in stools, Vertigo, Nausea and vomiting, Dyspnea, Redness, pain,swelling, blisters on the foot and hands, Mouth ulcer, Dark urine, Jaundice, Pain in chest, Stomach ache.
The storage condition of Tablet Sorafenat should be at 25oC (77oF); excursion are allowed between 15oC and 30oC (59oF and 86oF) Protect from moisture, heat and light
If patient missed to take Sorafenat tablet, then take the drug as you remember soon, Otherwise the missed dose should be skipped and follow the next dosing schedule. Do not double the dose. Please consult doctor regarding missed dose.
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