Torisel - 25mg


Description


Torisel 25mg belongs to an inhibitor of mTOR, mammalian target of rapamycin.
Torisel 25mg is a type of kinase inhibitor used as an antineoplastic agent. The mTOR kinase plays a role in stimulate a cascade that induces cell division, tumor growth and angiogenesis.
Torisel 25mg is a prescription drugs which is used under the supervision of medical oncologist.


Indication

Torisel 25mg is indicated for the treatment of advanced renal cell carcinomas.

Dosage and administration


Advanced Renal cell carcinoma :
Pre-treat with antihistamines (e.g. diphenhydramine 25-50 mg IV 30 minutes preinfusion
The recommended dose is 25mg IV infusion qweek until disease progression or unacceptable






Mechanism Of Action


Temsirolimus is a targeted cancer drug therapy known as an mTOR inhibitor. It stops the effects of a protein called mTOR which is often over active in cancer cells. This protein creates the cells multiply and grow.
Temsirolimus also blocks the cancer from creating blood vessels, that the cells require to be able to develop. This is known as anti-angiogenesis treatment. So Temsirolimus potency help to blocks the cancer growing or may reduce the growth of the cancer.

ADME


Absorption:
Time to peak plasma time is 0.5-2 hr after infusion (sirolimus)
Distribution:
volume of distribution is 172 L
Metabolism:
Metabolized in liver; through CYP3A4 to active metabolite sirolimus and several other metabolites
Elimination: excretion through feces 78% and urine <5% Half-Life: 17hr (Temsirolimus); 55hr (sirolimus)

Precautions


Infections may report from immunosuppression
Bowel perforation may result; monitor fever, abdominal pain, bloody stools, and/or acute abdomen immediately
Renal failure, sometimes fatal, has resulted; monitor renal function at baseline and while on therapy
Due to atypical wound healing, use caution in perioperative period
Elderly patients may be more likely to experience certain adverse reactions, containing diarrhea, edema and pneumonia

Drug Interaction


Torisel concomitant use with rifampin, a potent CY3A4/5 had no significant effect on Temsirolimus but reduced sirolimus Cmax by 65%.
Torisel concomitant use with ketoconazole, a potent CY3A4 inhibitor had no significant effect on Temsirolimus but have high sirolimus Cmax by 65%.
When concomitant use with ramipril and/or amlodipine, angioedema has been resulted in patients taking mammalian target of rapamycin

Side Effects


More common side effects :
Hypophosphatemia, Weakness, Low blood counts , Rash, Mouth sores , Increased liver enzymes, Nausea, Swelling , Poor appetite , Hyperglycaemia, High in blood cholesterol levels , Increased blood creatine levels.
Less common side effects for patients receiving Temsirolimus :
Weight loss, Chest pain , Headache , nail disorder/thinning , Insomnia , Nose bleed , Sore throat, Dry skin, Reduce white blood cell count, Generalized aches and pains , Shortness of breath , Pain, Swelling in legs and feet , Diarrhea , Cough , Fever , Low potassium , Abdominal pain, Infection, Constipation , Taste disturbance , Back pain , Itching, Vomiting .

Pregnancy


Pregnancy category is D
Avoid using Torisel during pregnancy

Lactation


The drug excreted into human milk is unknown and effects in the new born baby are unknown
Hence use is contraindicated
Avoid breastfeed during the treatment with Torisel



Missed Dose


If dose is missed, then have immediately before the reaching of next dose time or swap the missed dose and continue regular schedule. Consult the doctors for more information.


Storage


Store at 20- 80C
Protect from light


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