Votrient (pazopanib) - 400mg



About Votrient


Votrient (pazopanib) is a type of protein kinase inhibitors. It is also indicated for the treatment of advanced kidney cancer and soft tissue sarcoma Votrient 400mg is an antineoplastics medications which interfere with the development and spreadness of cancer cells in the body..


Dosage & Administration


Votrient dosage for renal cell carcinoma and soft tissue sarcoma (cancer in joints, muscle) will be initially 800mg , the dose adjustment in 400mg increments or decrements dose based on tolerance but max dose in adult is 800mg/day.
Moderate total bilirubin >1.5 to 3 times, Votrient dose of 400mg once daily.
Votrient should be taken on a empty stomach (1hr before or 2hr after meals.
Swallow the medicine whole don’t chew/crush.
Food interaction :Avoid grapefruit juice or grapefruit juice.





Usage Of Votrient 400mg


Votrient 400mg is used as a single agent to treat the renel cell carcinoma and its advanced stage It works by preventing the activity of proteins which are interferes with the growth and spread of cancer cells. Votrient 400mg is also used as a single regimen to treat the Soft Tissue Sarcoma, (a type of cancer that occurs in the supportive tissue of the body). The cancer can develop in muscles, blood vessels, fat tissue or in other tissues that support, surround and protect organs

Pharmacokinetics


Absorption :
Absorbed partially from the GI tract. Bioavailability is 14-39%. Time of peak plasma concentration: 2-4 hr. Greater absorption with food.
Distribution:
the drug has human protein serum concentration is >99%.
Metabolism:
Mainly in the liver the drug is metabolized by CYP3A4 enzyme and to a lesser extent by CYP1A2 and CYP2C8 enzymes.
Excretion:
Pazopanib primarily excreted through faeces approx 82%, 67% as unchanged drug and urine (<4%)with renal elimination. Terminal Elimination half-life: Approx 31 hr.

Votrient (Pazopanib) Mechanism Of Action


Votrient 400mg belongs to the classification of potent protein kinase inhibitor and selective multiple receptor tyrosine kinases (RTKs) which are define in beginning of signal transduction route that ready for multiplication of cancer cells and affect processes critical to cell survival and tumor breakthroughs . Stoppage of RTKs and includes the receptors for vascular endothelial growth factors (VEGFR-1, -2, and -3), platelet-derived growth factors (PDGFR-α and -β),pdgfra inhibitor and stem cell factor.


Drug Interaction


Strong CYP3A4 enzyme inhibitors (e.g. ketoconazole, itraconazole, voriconazole,etc) + Votrient 400mg → Increase plasma concentration.
Votrient + simvastatin → increases incidence of ALT elevation
Votrient 400mg + PPI e.g. esomeprazole → decreases bioavailability.
Concurrent use of strong of BCRP inhibitors or P-gp (e.g. lapatinib) and inducers + Votrient 400mg →alter the exposure and distribution of pazopanib.
Votrient 400mg + rifampin(strong CYP3A4 Enzyme inducers) →decreases the plasma concentration.

Precaution


Before to the treatment of Votrient 400mg tablets please consult the doctor for following condition → Allgeric to pazopanib or any other drug products of pazopanib, which include in prescription, over the counters,vitamins,herbal remedies. → Do not take immunization or vaccination without doctors advice. → Inform your doctor about pregnancy and planning to pregnant. → Do not breast feed while treatment with Votrient

Pregnancy


Category D: there is a positive effects for human fetal death but the benefits from use in pregnant women may be acceptable against the risk

Votrient (Pazopanib) Side Effects


Votrient 400mg has certain side effects, If any of the symptoms occrs or not cured then call the doctor immediately Major Votrient side effects : Diarrhae; High blood pressure; low WBC; Elevated liver function test; Blood test abnormalities; increased in bilirubin levels. Common Votrient Side effects: Nausea; loss of appetite; fatigue; blood test abnormalities (low magnesium, low glucose); weakness, stomach ache.

Storage


Votrient 400mg store at 20-250C. Votrient should store in locked cupboard in which children reach it. Votrient do not use after expiry date. Votrient must keep in its container till time to take the dose.

Over Dosage


If administrated, the votrient dosing upto 2000mg can be and It is evaluated in clinical trials and treatment of overdose with votrient should consist of supportive measures and there is no specific antidote.



Lactation


During breastfeeding the expert advice to either discontinue breastfeeding or the drug, in order to give importance of drug to the mother. The drug excreted into human milk and effects in the newborn baby is unknown.


Missed Dose


The drug dose is missed, and then takes the drug dose as soon as possible. If adjacent dose time reached then leave the missed dose and continue the routine schedule. Avoid taking 2 doses at one time. Please consult your doctor for further clarification.


Contraindication


Votrient 400mg is contraindicated with hypersensitivity or any of its excipients


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